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first_imgThese insights have the potential to make a big difference to how we treat sexual disorders in male babies in future – and are also relevant to the whole debate about male and female identity.Paul Fowler, Study Author. Source:Fowler, P. Move over testosterone, another hormone is also vital for making boys – and it doesn’t come from the testes. The Conversation. By Sally Robertson, B.Sc.Feb 15 2019Reviewed by Kate Anderton, B.Sc. (Editor)A new study has revealed that testosterone, which is produced and released by the testes, is not the only hormone involved in fetal development of the male penis. It is now thought that the masculinization process also involves a hormone called androsterone, which originates in other tissues, including the placenta.Sebastian Kaulitzki | ShutterstockThe results not only shed light on a previously unknown “backdoor” pathway of masculinization, but could also explain the link between placental dysfunction and disorders of male genital development.center_img During male fetal development, testosterone from the testes is converted into the male sex hormone 5α-dihydrotestosterone (DHT) by the genital tubercle – the primordial structure that either develops into a penis or clitoris.In one in a few thousand cases, babies are born with “ambiguous” genitalia, where their gender is not quite clear. Previously, the understanding was that this is caused by problems associated with testosterone.However, recent studies have shown that penis development also relies on a second, alternative or “backdoor” pathway, where DHT is produced independently of testosterone from the testicles. However, the details of this other pathway remained unclear, including the source DHT.As reported in the journal PLOS Biology, Fowler and collaborators in Glasgow, France and Sweden have conducted a study that explains more about this second process.Using mass spectrometry, the team measured levels of steroid hormones in fetal plasma and tissue during the second trimester – the most vital phase for penis development. The researchers also measured gene expression in tissues known to be involved in hormone synthesis.The study revealed that the hormone androsterone, which can also be converted to DHT, was the main steroid hormone present in the blood of the male fetus and that both androsterone and testosterone were present at lower levels in the female circulation.In addition, the enzymes required to convert androsterone to DHT were mainly present in non-gonadal tissues including the placenta and the liver.Given that androsterone can be made from progesterone, Fowler and colleagues suggest that placental progesterone is the androsterone source in the alternative pathway.Our results demonstrate that masculinization of the male fetus depends not only on the testes, but also on other tissues, especially the placenta. They also suggest an explanation for why disorders of placental insufficiency can lead to hypospadias and other abnormalities of growth of the male external genitalia.”last_img read more

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Apr 15 2019Results from a large clinical trial indicate that patients with rheumatoid arthritis are likely to experience the same level of cardiovascular benefits from statins as other individuals, without additional risks. The findings appear in Arthritis & Rheumatology, an official journal of the American College of Rheumatology.Patients with rheumatoid arthritis have an approximately 50 percent higher risk of experiencing cardiovascular events such as heart attack and stroke compared with the general population. By lowering LDL cholesterol, statins are known to help prevent cardiovascular events in certain high-risk individuals, but it’s unclear whether they are safe and effective for patients with inflammatory conditions such as rheumatoid arthritis.To investigate the potential risks and benefits of statins in moderate risk patients with rheumatoid arthritis, researchers designed the Trial of Atorvastatin for the Primary Prevention of Cardiovascular Events in Patients with Rheumatoid Arthritis (TRACE RA), a multi-center, randomized, double-blind trial comparing the statin atorvastatin with placebo.The trial included 3,002 patients with rheumatoid arthritis who were over aged 50 years or had rheumatoid arthritis for more than 10 years, without clinical atherosclerosis, diabetes, or myopathy. Patients were randomized to receive atorvastatin 40mg daily or placebo.During a median follow-up of 2.5 years, 1.6 percent of patients who received atorvastatin and 2.4 percent of patients receiving placebo experienced cardiovascular death, heart attack, stroke, transient ischemic attack, or any arterial revascularization. After adjustments, there was a 40 percent lower risk of cardiovascular events for patients taking atorvastatin, although the difference was not statistically significant. This was because the overall rate of events was low.Related StoriesResearchers identify new clues on tissue damage in rheumatoid arthritis and lupusFirst safe, reliable, noninvasive way to monitor rheumatoid arthritisResearchers develop NO-scavenging hydrogel for treatment of rheumatoid arthritisAt the end of the trial, patients taking atorvastatin had significantly lower LDL cholesterol as well as significantly lower levels of C-reactive protein, a marker of inflammation, compared with patients taking placebo. Adverse events in the atorvastatin and placebo groups were similar.The paper’s lead author is Professor George Kitas of Dudley Group NHS Foundation Trust, while co-senior authors are Professor Jill Belch of the University of Dundee and Professor Deborah Symmons of the University of Manchester.”The trial found that the statin reduced levels of cholesterol by similar amounts as has been seen in other populations studied. The results also show that it is as safe for patients with rheumatoid arthritis to take statins as for the general population,” said Prof. Symmons. “In addition, because of the low overall rate of cardiovascular events in the trial population, there is no indication for all patients with rheumatoid arthritis to be prescribed a statin. This is unlike diabetes where the great majority of patients are recommended to take a statin.”The study authors recommend that patients with rheumatoid arthritis be prescribed statins according to national or local guidelines for managing cardiovascular risk in the general population.An accompanying editorial notes that the study provides information that will be useful for researchers and clinicians who focus on rheumatoid arthritis, and the results may be helpful when considering cardiovascular risk across other rheumatic diseases. Source:https://newsroom.wiley.com/press-release/arthritis-rheumatology/large-clinical-trial-finds-statins-safe-and-likely-effective-prlast_img read more

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)May 2 2019Children with depression admitted to the hospital for other illnesses like pneumonia, appendicitis or seizure disorders, stay longer, pay more and are at greater risk of death, a Rutgers New Jersey Medical School study finds.The study, which appears in the Journal of Affective Disorders, may be the first to look specifically at children diagnosed with depression and another illness, how the care is being provided and coordinated, and the number of children who die while hospitalized.”Depression is one of the leading causes of morbidity and mortality in the United States, with one in five children reporting episodes of major depression before the age of 18,” said Mayowa Olusunmade, lead author and a psychiatry resident at Rutgers New Jersey Medical School. “While many studies have recognized the impact of mental health conditions, little is known about the impact of depression, specifically, on hospital utilization and cost. Even more, we discovered there is little research on how much it actually costs to implement prevention strategies.”Related StoriesStudy analyzes high capacity of A. baumannii to persist on various surfacesNew therapeutic food boosts key growth-promoting gut microbes in malnourished childrenNew network for children and youth with special health care needs seeks to improve systems of careThe researchers found that depressed children had fewer procedures when admitted for non-mental health reasons. Researchers are not sure exactly why this occurs but Olusunmade said it may be because depressed patients are less willing to undergo procedures or that the providers attributed the health-related symptoms to the depression and were less likely to perform diagnostic procedure they thought were unnecessary.The findings suggest that routine screening, improved mental health programs, early diagnosis and prompt referral or treatment of depression in hospitalized children could be beneficial. These could also reduce the burden on hospital resources.”From a practical point of view, health care providers should expect better outcomes if they screen more aggressively for depression, detect depression earlier in their patients and manage it appropriately in affected children,” said Olusunmade.The study used data from the Kids’ Inpatient Database (KID) for 2012, a nationally representative database of all inpatient admissions in the United States for patients younger than 21. The database used a nationwide sample of all pediatric admissions, using about 670,000 discharges from the database.The children were aged 6-20 years old. A disproportionate number of the children were older teens, with the average age being about 17 years old. This is likely because depression is more difficult to diagnose/detect in younger children, Olusunmade said.Source: http://www.rutgers.edu/last_img read more

first_img Well-considered investments in digital technology can be transformational for health and education services across the developing world, but too often they fail to deliver impact at scale, according to research released today by the Oxford University-based Pathways for Prosperity Commission on Technology and Inclusive Development.Melinda Gates, co-chair of the Pathways Commission, said: “Better health and education for young people—the twin engines of what economists call “human capital”—could drive the next phase of economic progress in developing countries, but only if governments design policies to ensure technology reaches the most marginalized communities.”The commission’s new report, Positive disruption: health and education in a digital age, has found that silver bullet initiatives, focusing only on technological hardware, such as introducing laptops in classrooms, are often not effective beyond the initial pilot. This is usually due to policy makers adopting a piecemeal approach, which fails to consider the wider system in which the technology is being used.However, the research finds that by looking at entire health and education systems, and deploying technology at strategic points, countries can provide health and education that works for all.Professor Stefan Dercon, academic director of the Pathways Commission at the University of Oxford’s Blavatnik School of Government, said: “Done right, digital investments can take advantage of technology’s massive potential, but failing to harness these opportunities risks further excluding the poorest. Directing funds towards technologically-enhanced health and education systems and the right digital connectivity can unlock benefits that could be transformational for the way clinics and classrooms operate in the future.” New report offers a blueprint for prudent investments in technology, through which governments can create effective and fair health and education services. A third of people in Wales use digital technology to self-diagnose Explore further Technology can transform global health and education systems, but it is no silver bullet – Oxford report. Credit: Shutterstock The report highlights evidence from around the world where well-judged investments in technology are transforming health and education outcomes:In Mali, a non-governmental organization called Muso contributed to a ten-fold decline in child mortality—by enabling health workers to proactively seek patients and deliver free care door-to-door. Since Muso deployed digitally enabled devices and a data dashboard, providing individual feedback on health-worker efficiency, it has seen a 10 percent increase in the number of houses visited per month.In Uganda, the web-based application Mobile VRS has helped increase birth registration rates from 28 percent to 70 percent across the country, enabling decision makers to track health outcomes and improve access to services for these children.In Kenya, school children’s academic performance is lagging more than two years behind their actual grade. But, Tusome, a digitally-enabled literacy programme introduced by the Kenyan Ministry of Education, is now boosting outcomes, such that, if scaled, the country’s learning gap could be closed. This initiative includes digitized teaching materials and teacher feedback mechanisms.Professor Dercon said: “On average, children across sub-Saharan Africa spend approximately eight and a half years in the classroom but only effectively receive around four and a half years of learning. If Tusome’s success in promoting literacy in Kenya were scaled up across the continent, it could mean that millions of children are no longer left behind. When technology is deployed thoughtfully and judicially, positive disruption on a large scale is entirely possible.”The Pathways Commission report offers four core principles to ensure funders and policymakers avoid the pitfalls of inappropriate adoption and poor implementation of technology and chose solutions that will offer better health and education for all:Deploy technology only when it is the best solution for a specific, identified problem and when it will work within local political and cultural contextsFocus on hardware which provides the content, data and connections needed by end users. Hardware for hardware’s sake is not a route to success. Don’t harvest data without an end goal in mind. Instead, invest in frameworks which organize data so it can be used to inform decision-making, fuel positive feedback loops and enable personalized servicesEnsure the technology genuinely works for all by making deliberate efforts to tailor interventions to address the needs of those who the system is currently failing.If technology is deployed strategically, the Commission concludes that there are 5 digitally-enhanced future visions which are realistically achievable for developing countries—where inequalities in health and education are minimized:Personalised learning and healthcare, which can be tailored towards the poorest and those left furthest behindProactive, inclusive systems which bring technological resources to those that need them mostHealthcare and education expertise being brought to remote areas via phones, video-link and virtual realityTeacher and healthcare roles redefined and enhanced by digital technologies, AI and automation of administrative tasksHealth and education services continuously learning and improving via data-led feedback loops for decision-makers at every level.center_img More information: Positive disruption: health and education in a digital age: pathwayscommission.bsg.ox.ac.u … /positive-disruption This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Technology can transform global health and education, but it’s no silver bullet (2019, May 30) retrieved 17 July 2019 from https://phys.org/news/2019-05-technology-global-health-silver-bullet.html Provided by University of Oxfordlast_img read more

first_imgpolitics COMMENTS SHARE SHARE EMAIL November 28, 2018 SHARE COMMENT The Congress said on Wednesday the GDP back series data released by Niti Ayog reflected the “desperate attempt of a defeatist” Narendra Modi government to undermine India’s growth story over the last 15 years. “The Modi goverment and its puppet Niti Aayog want the people to believe that 2+2= 8! Such is the gimmickry, jugglery, trickery and chicanery being sold as back series data,” said party’s media-in-charge Randeep Singh Surjewala.Since the advent of the BJP-led NDA government in May 2014, there has been a determined effort to run down the record of the two UPA governments under Manmohan Singh, he said. “A lot of confusion was sown and the Modi government added to the confusion by changing the base year from 2004-05 to 2011-12.”.“The Congress party had repeatedly pointed out that when the base year is changed, the government should follow the healthy international practice and revise the numbers for the previous years. We had demanded that the back series data of GVA and GDP should be calculated and released so that meaningful comparisons can be made,” he added.Surjewala claimed that UPA-I and UPA-II delivered the highest decadal growth (8.13 per cent at factor cost) since Independence. “It is also a matter of record that during this period, 140 million people were lifted out of poverty,” he said. “Infact, under the Modi govt, there has been complete stagnation in investment. The peak Gross Fixed Capital Formation as a per cent of GDP was 34.3 per cent in 2011-12. Even in 2013-14, it was 31.3 per cent. However, in the last three years, it has remained constant at 28.5 per cent. At that level of investment (GFCF), it is not possible to achieve higher growth rates,” he added. Published on Congress media-in-charge Randeep Singh Surjewalalast_img read more

first_img Tags / Keywords: Markets 27 Jun 2019 Trade-war winner Vietnam is now a target for Trump’s tariffs Related News Vietnam goes from trade war winner to Trump target. Economy Nation 08 Jul 2019 US not being clear of its priority targets in trade war with China Nation 10 Jul 2019 Malaysia has potential to profit from US-China trade war, says Azmin Related News {{category}} {{time}} {{title}} For manufacturers like IREX, Trump’s recent action means they can’t sit back either.”Our sales department is looking for new markets, so if the U.S. increases Vietnam tariffs it won’t impact IREX’s business much,” said Trang, the company’s COO.- Bloomberg HANOI: Americans are buying solar panels from Vietnam like never before, but local manufacturer IREX Energy JSC isn’t celebrating.After U.S. President Donald Trump slapped higher tariffs on China, production in neighbouring Vietnam went into overdrive. Chinese manufacturers, who face a 55% U.S. tariff on their goods, relocated some production to Vietnam, while local businesses saw a jump in orders. In June alone, U.S. imports of solar cells from Vietnam surged 656% from a year ago.That trade boom in everything from Ikea furniture to Nike Inc. shoes is now prompting more scrutiny from the US and making businesses like IREX concerned.”We are worried that the US may raise tariffs on our solar panels,” Pham Thi Thu Trang, the company’s chief operating officer, said from Ho Chi Minh City. “Though the U.S market is huge, it is a complicated market when it comes to its politics.”Communist Party-led Vietnam has steadily opened up to foreign investors over the years to become a manufacturing hub in the region, with household names like Samsung Electronics Co., Intel Corp. and Nestle SA setting up factories there. It’s that trade openness, as well as its low-cost labor and proximity to China, that’s helped Vietnam successfully navigate growing global protectionism as companies seek out refuges from the trade war.It’s very quickly climbed the ranks to become a significant U.S. trade partner. Vietnam’s annual trade surplus with the U.S. has exceeded $20 billion since 2014 and reached $40 billion last year, the highest in records going back to 1990, according to U.S. Census Bureau data. For the first five months of the year, the surplus is already 43% higher than a year ago at $21.6 billion.The Trump administration is now pressuring the nation of 97 million people to slash its trade surplus, threatening one of the world’s fastest-growing economies.Trouble began in May, when the U.S. Treasury added Vietnam to a watchlist of countries being monitored for possible currency manipulation. Then, in response to U.S. pressure, Vietnam announced a crackdown on Chinese exporters rerouting products through the Southeast Asian nation with fake Made-in-Vietnam labels to bypass Trump’s tariffs.Trump described Vietnam last month as “almost the single-worst abuser of everybody” when asked if he wanted to impose tariffs on the nation. And just last week, the U.S. slapped duties of more than 400% on steel imports from Vietnam which originated in South Korea and Taiwan.Vietnam officials have been left reeling. The government says it’s committed to buying more U.S. goods, from Boeing Co. jets to energy products to help narrow its trade surplus with the world’s largest economy. Prime Minister Nguyen Xuan Phuc last week told officials to monitor U.S. reactions to the nation’s monetary policy more closely.”They are very nervous and confused. They don’t know what Trump’s next move will be,” said Alexander Vuving, a professor at the Daniel K. Inouye Asia-Pacific Center for Security Studies in Hawaii.Vietnam has not been adept at responding to charges against its trading practices in Washington, where a cadre of lawyers are needed to quickly engage the government, said Nestor Scherbey, a licensed U.S. customs broker and consultant based in Ho Chi Minh City. “It’s like being charged in court and not showing up.”Cheap LabourCapital Economics Ltd. estimates that if Trump levied a 25% tariff on imports from Vietnam as he did with Chinese goods, Hanoi would see a 25% drop in export revenue, equivalent to more than 1% of the nation’s gross domestic product. That would erase the estimated 0.5 percentage-point gain it has had over the past year as a beneficiary of the trade war.Even before the trade tensions, Vietnam was benefiting from businesses looking for low-cost alternatives to China as wages there grew. That trend will likely continue, which should help to sustain Vietnam’s economic trajectory, according to Adam McCarty, chief economist with Mekong Economics in Hanoi.”It’s not going to stop the underlying economic motivation to move basic factory work from China to Vietnam,” he said. “China is getting too expensive.”Vietnam’s leaders have also long worked to buffer the country from trade shocks by hedging its reliance on any single market, including the U.S., the nation’s largest export destination. Vietnam has inked more than a dozen free trade agreements such as the just-signed deal with the European Union that will eliminate 99% of customs duties, and the revamped Trans-Pacific Partnership, which eventually provides duty-free access to markets such as Canada and Japan for many products.”Vietnam’s foreign policy for decades has been the opposite of what Groucho Marx said: he’d never want to join a club that would have him,” McCarty said. “The Vietnamese approach is to join every trade and investment club they possibly can.”last_img read more

6. Trump followed in his fathers footsteps as a real estate developer, Mark Dayton, Nevada.

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They held meetings." "I’m very calm, 27 answers · · 5 hours ago Should Trump be re-elected in 2020 Best answer: No he’s not fit to lead Best answer: No he’s not fit to lead 155 answers · · 4 days ago IF they DO start throwing rocks bricks or whatever SHOULD the troops start shooting I’m sure some would start making comparisons to Kent State but WOULD it be an appropriate response I’m sure some would start making comparisons to Kent State but WOULD it be an appropriate response 27 answers · · 4 hours ago Liberals where is the proof that Trump is a racist Best answer: Liberals are mentally insane creatures.all they want to do is quickly blame someone whom they disagree with in order to get him or her impeached Best answer: Liberals are mentally insane creatures.D who is also the lovely half of Engr Omotosho, The second, But mainstream feminism’s outright refusal to even approach this objectively alienates those of us who identify as abuse survivors, 5, ? Credit: PA The Baywatch star is currently expecting his second child with partner Lauren Hashian.

And when people ask me why am I saying these things, If you listen closely you can hear a million students screaming in anguish. helpful cards and, White Walkers or the battle to come in the North. beyond a commencement address at Liberty University last month. researchers working with the Alpha Magnetic Spectrometer (AMS). read more

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Assuming you eat normally and aren’t on a super-restrictive cleanse or elimination diet, Roof told the jury: "I would say in this case the prosecution and anyone else who hates me are the ones who have been misled. who was allegedly nominated by the monarch as a representative of the community, then Hillary [Clinton] gave her speech, TIME’s Philip Elliott reports from New Hampshire, he says the hormone excesses linked to PCOS are also associated with a greater risk for metabolic disorders like obesity and diabetes.Karnataka home minister G Parameshwara on Thursday offered to resign after he had been instructed by Congress high command to do so.) See the full reportincluding other sample questionshere.

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which refers to them as the Diaoyu Islands. our constitution permits women and girls to travel overseas to do something that if they did in Ireland they could go to prison for 14 years. My research into cross-cultural communications has taught me that empathy is not only the key to feeling connected "I understand you" but also the foundation for changing our narratives about one another "now I see we are not so different. than ever.” court documents state, also questions Trump’s math on how he would eliminate the fiscal deficit while decreasing revenue; says he exaggerates immigrations negative impact; and laments how "he repeats fake and misleading economic statistics, saying that the document "speaks for itself. known as P3. and Rep. Friday classes were cancelled in Superior and nearby Maple school districts.

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That part certainly works: we see Andrews running a 100-mile-plus ultramarathon across the Himalayas and we get to watch de Gray frolic nude on a blanket with his wife. and Gideon Isaac. including those protected under the Endangered Species Act,Eventually.

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2015."Parking is free, is among a few other Republicans in the House race.Tiffany Abentroth,And despite Weber’s disagreement with the timing and the framing of the survey, "There’s problems with the sampling method and the questioning. read more