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first_img Putting a crown on OMNIVAX ‘Robust protection’ Chan School’s Michael Mina urges federal regulatory approval, widespread use Cheap, frequent COVID tests could be ‘akin to vaccine,’ professor says Without trust, however, even those within the selected demographics may not universally embrace a vaccine. Bloom and his co-authors said a major information campaign may be needed that enlists both those who have retained the public’s confidence, such as doctors, nurses and pharmacists, and the private sector, whose expertise at communications and advertising far outstrips that of public health experts. They harkened to the one mounted by the March of Dimes, a nonprofit begun in the late 1930s that supported research that led to the introduction of the Salk polio vaccine in 1955.“High uptake of COVID-19 vaccines among prioritized groups should also not be assumed,” Bloom and co-authors wrote. “Many people in these groups will want to be vaccinated, but their willingness will be affected by what is said, the way it is said, and who says it in the months to come.” The vaccine technology could be used in vaccines against SARS-CoV-2 and beyond center_img The Daily Gazette Sign up for daily emails to get the latest Harvard news. Related COVID-weary Americans hanging on to the hope for a vaccine by year’s end and a quick return to pre-pandemic normality should get used to the idea that it could take some time before enough Americans are immunized, for a number of reasons, including skepticism over the treatment.“The most important ingredient in all vaccines is trust,” said Barry Bloom, the Joan L. and Julius H. Jacobson Research Professor of Public Health at the Harvard T.H. Chan School of Public Health. “Without trust a vaccine doesn’t do much good in the world.”Bloom, with co-authors Glen Nowak of the University of Georgia and Walter Orenstein of Emory University’s School of Medicine, wrote a recent “Perspective” article in the New England Journal of Medicine calling for a major effort to build public trust in an eventual vaccine. The three say that the gap between the 50 percent of Americans who’ve said they’d accept a COVID-19 vaccine and the 60 to 70 percent believed needed to reach the threshold for “herd immunity” — at which enough people are immune that transmission is interrupted — “will take substantial resources and active, bipartisan political support to achieve the uptake levels needed.” The estimated shortfall amounts to about 33 to 66 million Americans.Bloom, former dean of the Harvard Chan School, said in remarks to the media on Monday that misinformation distributed through social media and recent public tussles over the effectiveness of COVID treatments like hydroxychloroquine (which was granted emergency-use authorization, later revoked) have undermined public trust that vaccine candidates will be rigorously studied and widely administered only when determined safe and effective, without regard to political, economic, or other concerns.,Bloom has said that the challenge of manufacturing and distributing the estimated 200 million doses needed around the country is a tall one and that it would likely take months — possibly many months — to be completed and years for it to be available in some of the world’s poorest nations. Even then, he said this week, those generally skeptical of vaccines and those who have grown skeptical about this one have the potential to prevent even a widely available vaccine from interrupting transmission in the population.In a Facebook Live event sponsored by The Forum at Harvard T.H. Chan School of Public Health on Tuesday, Bloom complimented the vaccine effort so far, praising companies that have developed one and launched clinical trials in just months — a process that had previously taken years. He said that the recent suspension of the AstraZeneca trial due to illness of one of the subjects was not an indication of failure but a sign that the clinical trial process and its attendant safety features were working as designed. The trial has since been resumed in the U.K. after regulators there determined it was safe to do so.Bloom said it is likely that one of the vaccine candidates now in Phase 3 trials will have positive results in the months to come, and that it is possible that those results will be known by November, as President Trump has claimed. But Bloom cautioned that the trials have to be allowed to run until researchers can draw statistically meaningful conclusions. That is dependent not on the calendar, he said, but on the number of participants exposed to COVID-19 and the outcomes of their infection. Such trials typically involve tens of thousands of subjects.“It’s the data, not the date,” Bloom said.Once a vaccine is approved, Bloom and his NEJM co-authors wrote, distribution will be affected by which strategy is pursued. One focusing on limiting illness and death may target health care workers, nursing home residents, prison inmates, and others at highest risk. But that strategy, they pointed out, may not be the most effective at halting communitywide transmission. Such a plan would likely target essential workers, young people, and others who are responsible for most transmissions.[Robert Redfield, director of the Centers for Disease Control and Prevention, said during a Senate hearing Wednesday that the treatments would be given first to those most vulnerable. And he predicted that most Americans won’t have access to any vaccine until late spring or summer of next year at the earliest, according to The Washington Post.] COVID-19 vaccine candidate at Beth Israel prevents severe clinical disease in animals last_img read more

first_imgThe 2.3% return on investments at current value in the first nine months of this year compares with 3.1% in the same period last year.In the third quarter alone, Ilmarinen’s investments returned 2.9%, after 0.8% in the second quarter and a loss of 1.4% in the first.Ilmarinen’s total investments rose in value to €36.5bn at the end of September, from €35.2bn at the same point last year.The return on fixed income was 2% from January to September, up from just 0.1% in the same period last year.Fixed income investments shrank as a proportion of total assets, ending the quarter at 44.9% of the overall portfolio, down from 50.3% in September 2015.Listed and non-listed equities, shares and private equity investments increased as a proportion of assets, on the other hand, rising to a 39.1% allocation from 35.7%.In absolute figures, equities grew to €14.3bn from €12.6bn, but Ilmarinen said it reduced the amount of risk related to this asset class by €473m by using derivatives.The return on equities was 2% overall in the nine-month period, compared with 5.5% in the same period last year, with listed equities alone making a 0.2% loss.Property increased to make up 11.2% of Ilmarinen’s assets, having accounted for 8.8% of the whole portfolio at the end of September 2015, with indirect real estate investments contracting in allocation terms to 1.3% from 1.4%.This asset class generated a 2.8% return in January to September, up from 4.3% in the same period last year. Investment returns at Finnish pensions insurer Ilmarinen broke into positive territory on a year-to-date basis for the first time this year at the end of September, with the €36bn pension fund generating a 2.3% return in the first nine months of the year.Timo Ritakallio, president and chief executive, said: “The third quarter was a good one for Ilmarinen’s investment return, pushing the return from the start of the year clearly into positive figures.”A key factor behind the improvement in investment returns was the positive development in the equity markets, he said, adding that all of the main indices had performed well in the third quarter.“The historically low interest-rate level continues to steer investors towards alternatives such as real asset classes and stocks,” he said.last_img read more

first_img2G Robotics and Sonardyne International, UK, have entered into a formal collaboration agreement. The two organisations are working together on the development and promotion of a dynamic underwater laser mapping solution which reduces the time needed to survey seafloor sites and offshore structures.The new agreement centres on the integration of Sonardyne’s acoustically-aided inertial navigation system for underwater vehicles, Sprint-Mapper, with 2G Robotics’ ULS-500 Pro dynamic underwater laser scanner.The new technique uses the 2G Robotics ULS-500 Pro laser scanner fitted to an underwater vehicle to capture high density point clouds of subsea assets and environments.As the vehicle moves around the site, the Sprint-Mapper hardware, also fitted to the vehicle, simultaneously collects raw acoustic and inertial navigation data.On completion of the survey, the raw navigational data is post-processed and merged with the laser data to produce a geo-referenced 3D point cloud from which centimetric level or better engineering measurements can be taken.Edward Moller, global business manager for Construction Survey at Sonardyne said, “The level of detail visible in the post-processed images we’ve gathered on projects in recent months, has to be seen to be believed; small bolt-holes, individual chain links, marine growth and even painted markings can all be clearly seen. In terms of wide-area seabed visualization, it’s a real game-changer.”Chris Gilson, product development manager at 2G Robotics said, “This new partnership eliminates the complexities most subsea customers face when integrating multiple systems. The detail afforded by the integration of our technologies allows clients to not only capture superior data but also more effectively compete for projects.”last_img read more

first_img Cody Bellinger homer gives Dodgers their first walkoff win of season Kelly’s fastball was one of the fastest in MLB last year, averaging 98.1 mph during the regular season and 98.9 mph during the postseason when he topped out at 101.2 mph (the seventh-fastest pitch thrown during the 2018 playoffs).He appeared in all five World Series games for the Boston Red Sox, throwing six scoreless innings against the Dodgers. He allowed only four hits while striking out 10 of the 22 batters he faced and walking none.Related Articles LAS VEGAS — Joe Kelly has negatively impacted two Octobers for the Dodgers. Now they’re going to ask him to make a positive impact for them.The Dodgers have reached agreement on a contract with the free-agent reliever. The deal will pay Kelly $25 million over the next three years but is not official yet pending a physical. The Dodgers will also need to make an additional move to clear a spot on their 40-man roster, which could delay the official announcement.The $25 million investment represents a significant break from Andrew Friedman’s track record. With the Rays and now the Dodgers, Friedman has never given a contract that large to any non-closer reliever, preferring to build bullpens by collecting numerous relievers (or converted starters) with “compelling upside stories” and then hoping at least some of them reach those upsides.In Kelly, the Dodgers find a hard-throwing replacement for Brandon Morrow – something Friedman’s approach never did in 2018 – to anchor the setup crew in front of closer Kenley Jansen. Dodgers hit seven home runs, sweep Colorado Rockies But Kelly had given Dodgers fans something to remember him even before that. Kelly started Game 1 of the 2013 National League Championship Series for the St. Louis Cardinals and hit Hanley Ramirez with a pitch in the first inning. Ramirez suffered a fractured rib. The Dodgers’ offense – and their postseason hopes – withered with Ramirez playing hurt.The 30-year-old Kelly had an uneven career as a starter before being converted exclusively to relief with the Red Sox the past two years. His control has deserted him at times (4.3 walks per nine innings over the past two years) and that inconsistency has continued. Last season, he finished with a 4.39 ERA and 1.36 WHIP in the regular season – but he held batters to a .194 average in the first half, allowed just one earned run in May and two in August. How Dodgers pitcher Ross Stripling topped the baseball podcast empire Dodgers’ Max Muncy trying to work his way out of slow start Newsroom GuidelinesNews TipsContact UsReport an Error Fire danger is on Dave Roberts’ mind as Dodgers head to San Francisco last_img read more

first_imgRelated Posts A few days ago, we got a chance to talk about the state of blogging and social media in Germany with Marcel Weiß, the editor of Netzwertig.com – one of Germany’s most popular blogs. In the interview, Weiß told us that Germany is at least five years behind the U.S. when it comes to social media and its adoption by a larger part of society. Blogs are still considered to be suspect by a large part of the German public and have very little influence, and social news sites and aggregators attract very little attention. With regards to Germany’s Internet startup scene, Weiß argues that, with very few exceptions, most companies are also years behind the U.S. and just aren’t innovative enough to compete.Blogging in Germany: Five Years BehindWeiß argues that blogging and social media adoption in Germany is far behind similar trends in the U.S. and elsewhere in the world. Blogs are still considered suspect and have almost no influence over local or national politics. The mainstream media still likes to describe the Internet as a dangerous place, full of malware, porn, and scammers. While regular newspapers in Germany have also started to feel the pressure from the Internet (and every major German paper has a web site), the absence of a successful Craigslist-type site in the country has given the newspapers a longer lease on life than in America.Unlike the U.S., no political blog has the influence of American sites like DailyKos or Talking Points Memo, though a recent (and misguided) move by German politicians to censor the Internet in Germany in order to combat child pornography led over 130,000 German Internet users to sign a petition against this plan and galvanized the German Internet community in an unprecedented way. It remains to be seen, though, if this sudden rise in Internet activism in Germany will have legs, or if it will just fizzle out quickly. While political blogs in the U.S. also got a push during the Bush years when mainstream media outlets were generally seen as too close to the administration, German news outlets did not suffer from a similar pushback and most Germans still generally trust the mainstream media’s reporting and equate blogging with excessive over-sharers who write Internet diaries about their German Shepherds.In a post that created quite a stir in the German blogosphere (with a focus on blogging about economics), Felix Salmon argued that Germany’s culture was basically the antithesis of what blogging is all about. If this is true, then maybe there is really little hope for blogging in Germany in the near future, but at the same time, there are also a number of news blogs that are doing quite well (Netzwertig is one of them), and there are a lot of passionate German bloggers who are trying to change the current negative perception of blogs. The Absence of Social NewsUnlike in the U.S., the German blogosphere also doesn’t have large social news sites like Digg or Reddit to bring readers to blogs. With Yigg.de Germany has its own Digg clone, but it’s not only hampered by a rather unpleasant design, but even the top stories there hardly get more than 20 votes. In addition, a headline on Yigg or similar services like Webnews.de barely drives any traffic to a site.With regards, to blog monetization, things obviously also look equally bleak. Weiß told us that most companies still don’t quite get that they could find a very targeted audience on blogs – but of course, the fact that blogs are still struggling to find a large enough readership doesn’t exactly help matters here.StartupsTo some degree, the same is also true for the German startup scene, where, as Weiß argued, too many companies simply try to copy popular concepts that were developed elsewhere. The prime example for this is obviously StudiVZ, a blatant Facebook clone. Yet, while StudiVZ was able to quickly grow in Germany while Facebook was still ignoring most of the market outside of America, development of the site has now mostly come to a standstill and while Facebook is turning itself into a platform, the team behind StudiVZ has no interest in making any platform play whatsoever. Indeed, as Weiß told us, very few German startups are actually interested in the platform business and providing APIs for developers is still seen as unnecessary.That doesn’t mean that there aren’t some interesting and successful German startups, of course. Xing is a good example for a service that gets things right, and SoundCloud, a very cool music service based in Berlin is another one (though the founders are actually from Sweden). It’s important to note, though, that Germany never really had much of a startup scene and that there are a lot of cultural and bureaucratic barriers that would hold even some of the most determined founders from starting their own businesses. Outlook: Bleak – But With a Silver LiningThere are multiple reasons why blogging in Germany just isn’t taking off, but there is a chance that things might turn around this year. The upcoming election in Germany, for example, will give political blogs a chance to shine, especially if they manage to capitalize on the current discussion around Internet censorship. And while Twitter isn’t quite a mainstream phenomenon yet, the discussion around its use in Iran during the current controversy around the elections there, also brought Twitter into the spotlight in Germany.A number of Germany newspapers have also started to run blogs on their own sites, and with Rivva.de, the German blogosphere also has a very interesting meme-tracker that looks and feels similar to Techmeme and Memeorandum, and which provides a central focal point for the German blogosphere.Of course, in a piece like this, we can only touch upon a small number of examples and have to rely on some sweeping generalizations. Feel free to take issue with our (and Marcel’s) assessment of the German Internet scene and leave a comment.CC-Licensed image used courtesy of Flickr user Will Palmer. Top Reasons to Go With Managed WordPress Hosting 8 Best WordPress Hosting Solutions on the Market A Web Developer’s New Best Friend is the AI Wai…center_img frederic lardinois Why Tech Companies Need Simpler Terms of Servic… Tags:#NYT#Trends#web last_img read more

first_img Essential Reading! Get my first book: The Only Sale Guide You’ll Ever Need “The USA Today bestseller by the star sales speaker and author of The Sales Blog that reveals how all salespeople can attain huge sales success through strategies backed by extensive research and experience.” Buy Now It starts with an email. Well, not really an email from you, but an email from marketing made to look like it was from you. That email ended up in a spam filter, and your prospective client deleted it, along with a few more that looked a lot like it. This is the starting point of the experience, and it offers no real chance for the establishing of a relationship.It continues with another email. Like the email before it, there are links, the clicking of which is alleged to provide an indication of honest to goodness interest in you and your company. So far, the experience hasn’t been too great for you or your prospective client.In an act of desperation, you call your prospective client, and you leave a message asking them to call you back and leaving your phone number. For some reason, you have decided to give the task of connecting with you to the person you are actually trying to sell. No one understands why they should have to return a salesperson’s call, and your client, unmoved, deletes your voice mail.Back to email. Nothing. Back to voice mail. Nothing. Then, an answered telephone. Yes!You ask your prospective client if you can stop by, introduce yourself, and share all the ways that your company helps their clients, along with the story about how they hung both the Sun and the Moon in the sky. Your prospective client, with the slightest bit of interest, agrees to a meeting.You show up prepared. You have your slide deck, and you have your talking points. You also have questions you intend to use to elicit your prospective client’s needs. She says, “Tell me a little about you and your company.” You launch PowerPoint, and you begin at the beginning, history, buildings, locations, logos . . . your client, stifling a yawn, feigns interest. Then, you ask, “So, what keeps you up at night?”Fortunately, your prospective client has real issues, and she hopes you can help. So she lays out all of her challenges. Lacking an SME, you take meticulous notes, promising to get back to your prospective client with some answers, and you promise to schedule an appointment to bring someone with you to your next meeting. Your client asks, “Can you send me a proposal and some pricing?” You, anxiously agree.You send the pricing and the proposal by email, as requested. Your client gives it a very quick glance, and she leaves it in her inbox. She’s not sure she likes it. She’s not sure she doesn’t like it. She doesn’t know if she wants to show it to the rest of her team, or the leadership team who would need to approve any decision to buy from you.So, not hearing anything, you take the bold move of sending an email to follow up.This is a cautionary tale. There are good reasons for you to control the sales process, and chief among them is the buyer’s experience buying from you.last_img read more

first_imgNew South Wales and Queensland will battle it out in their quest to be 2014 champions when they meet at the Sunshine Coast Stadium for the 2014 State of Origin Series next week.   Teams from Under 20’s Boys and Girls through to Men’s 55’s will battle it out at on Friday, 19 September and Saturday, 20 September across three games per division.  The thinnest of margins proved the difference the last time the Origin series was contested with New South Wales narrowly edging-out Queensland 7-6  at Port Macquarie Regional Sports Stadium in September 2012. While New South Wales claimed the series and overall crown, it was Queensland who took bragging rights in the Open divisions, winning the blue ribbon Men’s and Women’s divisions, while New South Wales prevailed in the Mixed division. The stage is set for an exciting series, the countdown is well and truly on!The State of Origin Series will be run in conjunction with the 2014 National Youth Championships, which will run from Wednesday, 17 September through to Saturday, 20 September. Stay tuned to the State of Origin Series and Touch Football Australia websites for all of the latest news and information in the lead up to and during the 2014 State of Origin Series – www.soo.myclub.mytouchfooty.com and www.touchfootball.com.au. Keep in touch with Touch Football Australia in the following ways during the 2014 State of Origin Series:Facebook – www.facebook.com/touchfootballaustraliaTwitter – www.twitter.com/touchfootyaus (be sure to use the #SOO2014 and #origin hashtags)YouTube – www.youtube.com/touchfootballausInstagram – www.instagram.com/touchfootballaustralia (be sure to use the #SOO2014 and #origin hashtags)Website – www.austouch.com.auRelated LinksState of Originlast_img read more

first_imgKlopp deflects agent comments on Liverpool exit: It was German humour!by Freddie Taylora month agoSend to a friendShare the loveJurgen Klopp has brushed off comments from his agent saying he could leave Liverpool because of the weather.The Liverpool manager’s agent Marc Kosicke suggested in a recent interview that Klopp could be tempted to switch Merseyside for a hotter destination.Speaking on the eve of Liverpool’s Champions League opener against Napoli, Klopp said: “There is nothing in that story.”He wanted to make a joke so now I have to be serious.”It is German humour but obviously nobody got it…I am completely fine with the weather.”Let me spell it out, the weather has never been a reason for me to choose a city and it’s certainly not a reason for me to leave the country.”Maybe at the moment (in England) it’s the most healthy weather in the world – we have enough rain, it’s cool, pretty much the opposite of this room!”There’s nothing in that story. He’s my agent and my friend.”When I speak about the weather it was about the wind which can have an effect on football, but that is not allowed in England. But that is not to a reason leave the country. I am fine.” TagsTransfersAbout the authorFreddie TaylorShare the loveHave your saylast_img read more

first_imgMathias Pogba dismisses claims Real Madrid midfielder Valverde superior to brother Paulby Paul Vegas16 days agoSend to a friendShare the loveMathias Pogba has dismissed claims that Real Madrid midfielder Federico Valverde is superior to brother Paul.Valverde’s recent emergence has prompted suggestions Real coach Zinedine Zidane may end his pursuit of Manchester United ace Paul Pogba.But CD Manchego striker Mathias believes Zidane could still do with his brother’s services, insisting the World Cup winner ‘is better’ than the youngster.“Of course [he’s better than Valverde],” Mathias said of his sibling during an appearance on El Chiringuito. “My brother is better than Valverde technically, and has better vision of the game.”He later added: “Right now, my brother is better.” TagsTransfersAbout the authorPaul VegasShare the loveHave your saylast_img read more

first_imgKINGSTON, Ont. – Two eastern Ontario teens are facing charges after a social media argument escalated into a fight with weapons on a front yard.Police in Kingston, Ont., say two girls became involved in an argument over social media on Sunday and it escalated to the point where one of them proposed they settle their differences in a fight.They say the complainant went out to her front yard and saw the other girl and a boy approaching and calling her names. It’s alleged the boy fired a pellet gun at the complainant multiple times and missed, at which point the other girl pulled out a knife.Police say the alleged victim struck the girl, causing her to drop the knife, and the two engaged in a physical struggle during which the complainant’s face was scratched and she was kicked several times by the boy.The alleged assailants fled when neighbours said they were calling police and the complainant was taken to hospital for treatment of minor injuries.A boy and girl — both 17 — surrendered to police on Monday. He is charged with two counts of assault with a weapon and assault, while she faces one count of assault with a weapon.last_img read more